The compound, Discorhabdin C comes under pyrroloiminoquinone alkaloid family was synthesized by the reaction of conversion of aminoindoloquinone imine into its corresponding silylether and the subsequent oxidative coupling reaction using PIFA. Due to their prominent potent antitumor activity, discorhabdins have attracted considerable attention. Many studies have been reported toward the synthesis of discorhabdins. Along with co-crystal ligand, induced fit docking study was carried out for the compound Discorhabdin C for comparison. The oxygen atom of the co-crystal ligand interacts with the oxygen atom of the residue GLU 305 at a distance of 1.7Ã?â?¦ with the docking score of âË?â??7.51 and glide energy of âË?â??69.35 kcal/mol and the nitrogen atom attached with the phenyl ring interacts with the residue (ASN483) at a distance of 2.7 Ã?â?¦ with the glide score of âË?â??7.51 and glide energy of -69.35 kcal/mol and also interacts with same residue at a distance of 2.2Ã?â?¦ of Discorhabdin C. The cancer cell line MCF-7cells were used to check anticancer activity. It showed exponential responses towards the increasing concentration of compound and their IC50 value is 17 Ã?¼g/ml against the MCF-7 cells.
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